- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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PRL antibody detects prolactin, a peptide hormone encoded by the PRL gene. Prolactin is secreted by the anterior pituitary and plays diverse roles in lactation, reproduction, metabolism, and immune regulation. Because prolactin is implicated in endocrine signaling and disease states ranging from infertility to cancer, PRL antibody is widely used in endocrinology, oncology, and reproductive biology.
Prolactin is a 23 kDa polypeptide hormone structurally related to growth hormone and placental lactogen. It acts via the prolactin receptor, a member of the cytokine receptor superfamily, activating JAK2/STAT5 signaling pathways. While best known for stimulating mammary gland development and milk production, prolactin also influences immune tolerance, angiogenesis, and osmoregulation. Dysregulation of prolactin signaling contributes to pituitary adenomas, hyperprolactinemia, and hormone-dependent cancers.
The PRL antibody clone rPRL/4907 provides consistent and specific recognition. Recombinant production ensures lot-to-lot uniformity, which is essential for hormonal research. Clone rPRL/4907 has been cited in peer-reviewed studies examining pituitary tumors, reproductive endocrinology, and cytokine signaling. Its applications include immunohistochemistry, immunoblotting, and ELISA-based detection.
Research using clone rPRL/4907 has clarified how prolactin secretion is regulated by dopamine and how aberrant levels contribute to infertility and endocrine disorders. In oncology, PRL detection has supported studies of breast and prostate cancer, where prolactin promotes cell survival and tumor growth. Beyond endocrinology, research has highlighted prolactinâs influence on immune tolerance, linking it to autoimmune disease regulation. This antibody enables precise analysis of prolactin expression across these diverse contexts.
NSJ Bioreagents provides this PRL antibody to support endocrinology, oncology, and reproductive biology research. Alternate designations include prolactin antibody, lactogenic hormone antibody, pituitary hormone antibody, mammary gland development hormone antibody, cytokine receptor ligand antibody, and PRL gene product antibody.
Optimal dilution of the PRL antibody should be determined by the researcher.
A portion of amino acids 63-201 was used as the immunogen for the PRL antibody.
Aliquot the PRL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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