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Home >> Antibodies >> Prion protein Antibody (PrP)

Prion protein Antibody (PrP) (R30893)

  Catalog No Formulation Size Price (USD)  
Image R30893 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of Prion protein antibody and Lane 1: rat brain; 2: rat brain. Expected molecular weight: 20~29kDa.
IHC-P: Prion protein antibody testing of rat brain tissue
Availability 1-3 business days
Species Reactivity Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P04925
Localization Cytoplasmic
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This Prion protein antibody is available for research use only.
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Description

Prion protein, also known as CD230 and PRP, is encoded by the PRNP gene. The major prion protein is expressed in the brain and several other tissues. Expression is most predominant in the nervous system but occurs in many other tissues throughout the body. Puckett et al.(1991) identified a RFLP with a high degree of heterozygosity in the 5-prime region of the PRNP gene, which might serve as a useful marker for the pter-p12 region of chromosome 20. PRNP is associated with a variety of cognitive deficiencies and neurodegenerative diseases such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and kuru.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the Prion protein antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the middle region of mouse Prion protein (DWEDRYYRENMYRYPNQ) was used as the immunogen for this Prion protein antibody (100% rat homology).

Storage

After reconstitution, the Prion protein antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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