- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MAPKAPK5 Antibody / ERK3 Signaling Kinase (R35126)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R35126-100UG | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse |
| Predicted Reactivity | Rat, Dog, Pig, Cow |
| Format | Antigen affinity purified |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| Gene ID | 8550 |
| Applications | Western Blot : 0.5-1.5ug/ml Immunohistochemistry (FFPE) : 4-8ug/ml Immunoprecipitation : suitable ELISA (peptide) LOD : 1:64000 |
| Limitations | This MAPKAPK5 Antibody / ERK3 Signaling Kinase is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
MAP kinase-activated protein kinase 5 (MAPKAPK5) is a stress-responsive serine/threonine kinase encoded by the MAPKAPK5 gene and functions within signaling pathways associated with ERK3, ERK4, and p38 MAP kinase activity. MAPKAPK5 Antibody / ERK3 Signaling Kinase is useful for studying atypical MAP kinase signaling, cellular stress adaptation, migration pathways, and kinase-mediated transcriptional regulation. MAPKAPK5 is commonly referred to as PRAK or MK5 and serves as an important downstream signaling intermediate in stress-responsive cellular networks.
MAPKAPK5 antibody, also known as PRAK antibody or MK5 antibody in published studies, recognizes a kinase that interacts closely with atypical MAP kinases ERK3 and ERK4. These signaling interactions contribute to regulation of cytoskeletal organization, cellular motility, senescence pathways, and stress-responsive gene expression. PRAK has additionally been implicated in inflammatory signaling, tumor suppression, and adaptation to oxidative or metabolic stress conditions.
MAPKAPK5 demonstrates dynamic intracellular localization and may shuttle between cytoplasmic and nuclear compartments depending on activation state and signaling context. Nuclear-associated PRAK activity has been linked to transcriptional regulation and stress-responsive signaling mechanisms, while cytoplasmic signaling contributes to actin remodeling and migration-associated pathways. The kinase therefore occupies a central role connecting atypical MAP kinase signaling with cellular stress adaptation and survival responses.
PRAK signaling has been investigated in cancer biology, inflammatory disease, senescence, and cellular responses to environmental stress. The kinase participates in pathways associated with p53 regulation, cytoskeletal dynamics, and kinase-mediated control of stress-responsive transcriptional programs. Because ERK3-associated signaling networks remain comparatively understudied relative to canonical MAP kinase pathways, MAPKAPK5 represents an important target for mechanistic studies of atypical MAP kinase biology.
MAPKAPK5 is encoded on chromosome 12q24 and produces a conserved serine/threonine kinase containing regulatory and catalytic motifs characteristic of MAP kinase-activated protein kinases. The protein functions in concert with ERK3, ERK4, and p38-associated signaling intermediates involved in stress adaptation and cellular regulation.
This goat polyclonal MAPKAPK5 antibody has been supported using knockout, rescue, overexpression, and immunoprecipitation validation methods to support selective endogenous PRAK detection in research applications. Knockout and rescue studies demonstrate specific detection of MAPKAPK5 in genetically modified cell systems, while overexpression experiments support selective recognition relative to related kinase family members. These validation approaches support use of the antibody in studies of ERK3-associated signaling and atypical MAP kinase pathway biology.
For broader analysis of PRAK biology and p38-mediated stress signaling pathways, explore the PRAK Antibody / p38-Regulated Stress Kinase page featuring expanded validation data for endogenous MAPKAPK5 detection and stress-response kinase pathway research.
Optimal dilution of the MAPKAPK5 Antibody / ERK3 Signaling Kinase should be determined by the researcher.
Amino acids PQVLEAQRRHQKEKS were used as the immunogen for this PRAK antibody.
Aliquot and store the PRAK antibody at -20oC.
PRAK antibody, MK5 antibody, MAP kinase-activated protein kinase 5 antibody, ERK3-associated kinase antibody, MAPKAPK5 stress signaling antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
