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Home >> Antibodies >> PP14 Antibody / Placental protein 14 / PAEP / ZIF-1

PP14 Antibody / Placental protein 14 / PAEP / ZIF-1 (RQ7927)

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  Catalog No Formulation Size Price (USD)  
Image RQ7927 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human placental tissue with PP14 antibody. Predicted molecular weight ~21 kDa but may be observed at higher molecular weights due to glycosylation.
Western blot testing of human placental tissue with PP14 antibody. Predicted molecular weight ~21 kDa but may be observed at higher molecular weights due to glycosylation.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt P09466
Applications Western blot : 0.5-1ug/ml
Direct ELISA : 0.1-0.5ug/ml
Limitations This PP14 antibody is available for research use only.
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Description

Glycodelin (GD) also known as human placental protein-14 (PP-14) progestogen-associated endometrial protein (PAEP) or pregnancy-associated endometrial alpha-2 globulin is a glycoprotein that inhibits cell immune function and plays an essential role in the pregnancy process. In humans is encoded by the PAEP gene. This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants.

Application Notes

Optimal dilution of the PP14 antibody should be determined by the researcher.

Immunogen

E. coli-derived recombinant human protein (amino acids M19-F180) was used as the immunogen for the PP14 antibody.

Storage

After reconstitution, the PP14 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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