- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
POGZ Antibody / Chromatin Regulation Marker [clone PCRP-POGZ-1B2] (V4095)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4095-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V4095-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4095SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b |
| Clone Name | PCRP-POGZ-1B2 |
| Purity | Protein A/G affinity |
| UniProt | Q7Z3K3 |
| Localization | Nucleus |
| Applications | Flow Cytometry : 1-2ug/million cells |
| Limitations | This POGZ Antibody / Chromatin Regulation Marker is available for research use only. |
|
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Pogo transposable element-derived protein with zinc finger domain (POGZ) is a chromatin-associated regulatory protein involved in transcriptional control, chromatin organization, and developmental gene expression pathways. POGZ Antibody / Chromatin Regulation Marker is suitable for investigations involving nuclear regulatory proteins, neurodevelopment-associated signaling pathways, and chromatin-associated transcriptional control mechanisms. POGZ contains multiple zinc finger domains and protein interaction motifs that contribute to regulation of chromatin structure and coordinated gene expression programs.
POGZ antibody, also referred to as Pogo transposable element-derived protein with zinc finger domain antibody, Zinc finger chromatin regulator antibody, and HP1-binding protein antibody in the literature, recognizes a nuclear-associated regulatory protein implicated in chromatin remodeling and transcription-associated signaling pathways. POGZ has been reported to interact with heterochromatin-associated proteins including HP1 family members and is linked to regulation of mitotic chromosome organization, transcriptional modulation, and developmental gene expression networks. The protein is primarily localized within the nucleus, consistent with its role in chromatin-associated regulatory processes.
Chromatin regulatory proteins such as POGZ participate in pathways controlling cellular differentiation, developmental signaling, proliferation, and maintenance of transcriptional homeostasis. POGZ has attracted significant interest in neurodevelopmental biology because altered expression or mutation of the gene has been associated with autism spectrum disorders, intellectual disability syndromes, and developmental abnormalities involving transcriptional and chromatin-associated regulatory pathways. Through modulation of chromatin accessibility and gene expression programs, POGZ contributes to coordinated developmental and differentiation-associated signaling networks.
Zinc finger regulatory proteins frequently function within multiprotein nuclear complexes that integrate chromatin organization with transcriptional regulation. POGZ has additionally been linked to pathways involved in mitotic progression, chromosome segregation, and maintenance of genomic regulatory architecture. Because chromatin-associated transcriptional regulators coordinate broad developmental and signaling-associated programs, POGZ remains relevant for studies examining nuclear gene expression control, developmental signaling pathways, and chromatin-associated disease mechanisms.
Flow cytometry analysis supports detection of endogenous POGZ expression in human cells. HuProt(TM) protein microarray specificity validation with clone PCRP-POGZ-1B2 further demonstrates highly selective recognition of POGZ among more than 19,000 full-length human proteins. The combined validation profile supports use of this mouse monoclonal antibody for investigations involving chromatin regulation, transcription-associated signaling pathways, developmental gene expression programs, and zinc finger nuclear regulatory proteins.
An antibody targeting POGZ can therefore support studies involving chromatin-associated transcriptional regulation, developmental signaling pathways, neurodevelopmental biology, nuclear regulatory complexes, and zinc finger protein-mediated gene expression control.
POGZ functions in chromatin-associated transcriptional regulation and developmental signaling pathways; explore related nuclear regulatory proteins and cellular pathway targets on our Cell Biology Antibodies landing page.
Optimal dilution of the POGZ Antibody / Chromatin Regulation Marker should be determined by the researcher.
Recombinant full-length human Pogo transposable element with ZNF domain protein was used as the immunogen for the POGZ antibody.
Aliquot the POGZ antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
POGZ antibody, Pogo transposable element-derived protein with zinc finger domain antibody, Zinc finger chromatin regulator antibody, HP1-binding protein antibody, Neurodevelopmental regulatory protein antibody
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