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  • Email: info@nsjbio.com
Home >> Antibodies >> PMVK Antibody

PMVK Antibody (R30248)

  Catalog No Formulation Size Price (USD)  
R30248 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of PMVK antibody and rat heart tissue lysate
IHC-P: PMVK antibody testing of rat skeletal muscle tissue
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt Q15126
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This PMVK antibody is available for research use only.
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Description

Phosphomevalonate kinase is a cytosolic enzyme that catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate. It is mapped to chromosome 1p13-1q22-23 and spans more than 8.4 kb in the human genome. PMVK is a peroxisomal protein which requires the C-terminal peroxisomal targeting signal, Ser-Arg-Leu, for localization to the organelle. It was expressed highly in heart, liver, skeletal muscle, kidney and pancreas and slightly lower in brain, placenta, and lung. And PMKase gene expression is subject to regulation by sterol at the level of transcription. It is a single copy gene covering less than 15 kb in the human genome. The human PMKase amino acid sequence contains a consensus peroxisomal targeting sequence(PTS-1), Ser-Arg-Leu, at the C terminus of the protein.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the PMVK antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the middle region of human PMVK (EQSRQQRGWVFTPGVDD) was used as the immunogen for this PMVK antibody (100% homologous in human and mouse).

Storage

After reconstitution, the PMVK antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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