- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PMVK Antibody / Phosphomevalonate kinase (FY12789)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12789 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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PMVK antibody detects Phosphomevalonate kinase, a key enzyme in the mevalonate pathway responsible for cholesterol and isoprenoid biosynthesis. Encoded by the PMVK gene on chromosome 1q21.3, this cytosolic enzyme catalyzes the ATP-dependent phosphorylation of mevalonate 5-phosphate to mevalonate 5-diphosphate, an essential step linking early mevalonate metabolism to downstream sterol and non-sterol isoprenoid synthesis. The mevalonate pathway provides precursors for cholesterol, dolichols, ubiquinone, and prenylated proteins that regulate membrane integrity and signal transduction.
PMVK operates downstream of HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. Its activity is tightly controlled by cellular sterol levels and feedback mechanisms that balance lipid production with energy demands. Beyond lipid metabolism, PMVK influences cell proliferation, differentiation, and apoptosis by modulating isoprenoid-dependent signaling pathways. It localizes to both the cytosol and peroxisomes, reflecting its versatile role in cellular metabolism.
The PMVK antibody is widely used in metabolism, lipid biology, and pharmacology research to study cholesterol regulation and mevalonate pathway dynamics. Western blot analysis detects a 21 kilodalton band corresponding to PMVK, while immunofluorescence shows cytoplasmic and peroxisomal staining. This antibody enables quantification of PMVK expression in response to statin treatment or metabolic stress, supporting studies of lipid homeostasis and biosynthetic control.
Altered PMVK expression has been linked to hypercholesterolemia, metabolic disorders, and cancer cell survival, where mevalonate flux influences oncogenic signaling and membrane biosynthesis. The PMVK antibody is a valuable reagent for characterizing cholesterol metabolism, isoprenoid synthesis, and metabolic adaptation. NSJ Bioreagents provides this antibody validated for its applications, ensuring reproducible performance in metabolic research.
Optimal dilution of the PMVK antibody should be determined by the researcher.
E.coli-derived human PMVK recombinant protein (Position: K22-L192) was used as the immunogen for the PMVK antibody.
After reconstitution, the PMVK antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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