• Tel: 858.663.9055
  • SeparatorEmail: info@nsjbio.com
  • Tel: 858.663.9055
  • Email: info@nsjbio.com
Home >> Antibodies >> PLIN2 Antibody / Perilipin Family Protein

PLIN2 Antibody / Perilipin Family Protein [clone ADFP/1493] (V3206)

NSJ bio Image Pdf Image
  Catalog No Formulation Size Price (USD)  
Image V3206-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 559
Image
V3206-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 259
Image
V3206SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 559
Bulk quote request
PLIN2 Antibody Human Placenta IHC. Immunohistochemical staining of FFPE human placental tissue using PLIN2 antibody (clone ADFP/1493) demonstrated predominantly cytoplasmic staining within placental trophoblasts, consistent with the localization of PLIN2 to intracellular lipid droplets. Heat-induced epitope retrieval was performed by steaming tissue sections in pH6, 10 mM citrate buffer for 10-20 minutes prior to staining. The observed staining pattern is consistent with the role of PLIN2 in lipid storage, fatty acid metabolism, and placental lipid homeostasis. This PLIN2 Antibody, also called a Perilipin Family Protein Antibody, is useful for investigating lipid droplet biology, placental physiology, and metabolic regulation.
Species Reactivity Human
Format Purified
Host Mouse
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, lambda
Clone Name ADFP/1493
Purity Protein G affinity chromatography
Buffer 1X PBS, pH 7.4
Gene ID 123
Localization Cytoplasmic
Applications ELISA (order BSA/sodium Azide-free Format For Coating) :
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This PLIN2 Antibody / Perilipin Family Protein is available for research use only.
Review this product on BioCompare and get a $20 Amazon gift card

Related Products

Description

PLIN2 Antibody / Perilipin Family Protein, clone ADFP/1493, recognizes PLIN2, the gene encoding Perilipin 2, a member of the perilipin family of lipid droplet-associated proteins. PLIN2 is widely expressed in metabolically active tissues including liver, skeletal muscle, macrophages, kidney, adrenal gland, and numerous epithelial cell types, where it coats the surface of intracellular lipid droplets. By stabilizing neutral lipid stores and regulating interactions with lipid metabolic enzymes, PLIN2 plays a central role in triglyceride storage, fatty acid metabolism, and cellular energy homeostasis. Because of its broad tissue distribution and abundant expression on lipid droplets, PLIN2 has become one of the most widely studied members of the perilipin protein family.

As a perilipin family protein, PLIN2 protects lipid droplets from uncontrolled lipolysis while coordinating lipid storage and mobilization according to cellular metabolic demands. Expression is strongly induced by lipid loading, oxidative stress, and activation of lipid-responsive transcription factors, resulting in increased lipid droplet formation in many cell types. Consequently, PLIN2 serves as a sensitive marker of intracellular lipid accumulation in hepatocytes, macrophages, adipocytes, and cultured cells. Research involving PLIN2 has contributed substantially to current understanding of lipid droplet biogenesis, organelle dynamics, membrane lipid metabolism, and cellular adaptation to metabolic stress.

Altered PLIN2 expression has been associated with obesity, nonalcoholic fatty liver disease, diabetes, atherosclerosis, and numerous cancers. Many tumors accumulate abundant lipid droplets to support rapid proliferation and metabolic reprogramming, leading to increased PLIN2 expression that can be evaluated by immunohistochemistry and other laboratory methods. PLIN2 has also become an important biomarker in studies of chronic inflammation, hepatic steatosis, adrenal cortical tumors, sebaceous neoplasms, and renal cell carcinoma, where altered lipid metabolism contributes to disease progression. Ongoing investigations continue to explore the relationship between PLIN2, oxidative stress, inflammation, and tumor biology.

A PLIN2 Antibody is a valuable research tool for investigating perilipin family proteins, lipid droplet biology, lipid metabolism, cellular energy homeostasis, metabolic disease, and lipid-rich tumors.

This PLIN2 Antibody antibody complements a related Adipophilin antibody targeting ADRP, PLIN2, and Perilipin 2.

Application Notes

Titering of the PLIN2 Antibody / Perilipin Family Protein may be required for optimal performance.

Immunogen

A human partial recombinant protein was used as the immunogen for this PLIN2 antibody.

Storage

The PLIN2 antibody (with azide) can be stored at 2-8oC. The azide-free format should be aliquoted and stored at -20oC or colder.

Alternate Names

PLIN2 antibody, Perilipin Family Protein antibody, Perilipin 2 antibody, Adipophilin antibody, ADRP antibody

Related Products

   1.   View all Adipophilin / Perilipin 2 antibodies

Cross
Bulk Quote Request Form
Name*:
Organization*:
Email*:
Phone Number*:
Catalog No.*:
Comments and Specifics(amount, formulation, etc.)*:
Validation code: Captchapackage Image


Can't read the image? click here to refresh.
    *required field

Your bulk quote request has been submitted successfully!

Please contact us if you have any questions.