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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Pleiotrophin Antibody / PTN [clone 32P54] (FY12423)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12423 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 439 |
| Availability | 2-3 weeks |
| Species Reactivity | Human, Mouse, Rat |
| Format | Liquid |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | 32P54 |
| Purity | Affinity-chromatography |
| Buffer | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| UniProt | P21246 |
| Localization | Cytoplasm, cell membrane |
| Applications | Western Blot : 1:500-1:2000 Immunohistochemistry : 1:50-1:200 |
| Limitations | This Pleiotrophin antibody is available for research use only. |
|
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Pleiotrophin antibody detects pleiotrophin, a secreted heparin binding growth factor encoded by the PTN gene. Pleiotrophin is a cytokine involved in the regulation of cell growth, survival, differentiation, and migration. It is highly expressed during embryonic development, where it contributes to neurogenesis, angiogenesis, and skeletal formation. In adult tissues, pleiotrophin expression is limited but becomes re induced during tissue repair and tumorigenesis.
Pleiotrophin antibody is applied in developmental biology, oncology, and regenerative medicine research. The protein interacts with receptors such as receptor protein tyrosine phosphatase beta zeta, syndecans, and anaplastic lymphoma kinase, activating signaling cascades including PI3K AKT and MAPK. These pathways promote proliferation and survival, making pleiotrophin an important regulator of both physiological and pathological growth. Detecting pleiotrophin provides insight into how extracellular cues influence signaling and cell fate decisions.
The antibody is validated for western blotting, immunohistochemistry, immunofluorescence, and ELISA. In western blot assays, pleiotrophin antibody identifies bands corresponding to the growth factor across tissue extracts. Immunohistochemistry reveals expression in vasculature and developing tissues, while immunofluorescence highlights extracellular distribution and receptor colocalization. ELISA applications allow quantification of secreted pleiotrophin in culture media or patient samples.
Overexpression of pleiotrophin has been reported in cancers including glioblastoma, breast carcinoma, and prostate cancer. In these contexts, pleiotrophin enhances angiogenesis, invasion, and tumor progression. By applying pleiotrophin antibody, scientists can evaluate pleiotrophin levels as a biomarker and investigate its potential as a therapeutic target.
In neuroscience, pleiotrophin plays roles in neuronal survival, synaptic plasticity, and axonal regeneration after injury. It promotes neurite outgrowth and supports recovery in models of neural damage. In skeletal biology, pleiotrophin regulates osteoblast differentiation and bone growth, linking it to both normal development and fracture healing. These diverse functions demonstrate the broad research value of pleiotrophin antibody.
Pleiotrophin antibody provided by NSJ Bioreagents offers reliable specificity for detecting this multifunctional growth factor. Its strong performance across multiple applications makes it an important tool for investigating pleiotrophin in development, disease, and regeneration.
Optimal dilution of the Pleiotrophin antibody should be determined by the researcher.
A synthesized peptide derived from human Pleiotrophin was used as the immunogen for the Pleiotrophin antibody.
Store the Pleiotrophin antibody at -20oC.
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