- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Placental Protein 5 Antibody / TFPI2 [clone TFPI2/13028] (V6023)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V6023-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V6023-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V6023SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2, kappa |
| Clone Name | TFPI2/13028 |
| UniProt | P48307 |
| Localization | Secreted |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Placental Protein 5/TFPI2 antibody is available for research use only. |
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Placental Protein 5 antibody, also known as TFPI2 antibody, recognizes Placental Protein 5, the historical name for Tissue factor pathway inhibitor 2 encoded by the TFPI2 gene. Originally identified in placental tissue, Placental Protein 5 is a secreted Kunitz-type serine protease inhibitor that associates with the extracellular matrix and regulates pericellular proteolysis. The protein contains three tandem Kunitz domains that enable inhibition of multiple serine proteases involved in matrix degradation and tissue remodeling. Placental Protein 5 antibody is widely used in research examining extracellular matrix regulation, trophoblastic biology, and tumor invasion mechanisms.
TFPI2 is synthesized with a signal peptide and secreted into the extracellular environment, where it binds matrix components and modulates local protease activity. Although structurally related to Tissue factor pathway inhibitor 1, Placental Protein 5 primarily functions in extracellular matrix homeostasis rather than directly regulating the tissue factor coagulation cascade. By inhibiting proteases such as plasmin and trypsin-like enzymes, TFPI2 contributes to maintaining tissue integrity and limiting excessive matrix breakdown. Reduced TFPI2 expression has been reported in various malignancies, often associated with promoter hypermethylation and increased invasive potential.
Expression of Placental Protein 5 has been documented in placenta, vascular endothelium, and selected epithelial tissues. In placental tissue, extracellular and pericellular localization patterns are consistent with its matrix-associated inhibitory role. In cancer biology studies, TFPI2 antibody is frequently used to evaluate epigenetic silencing, stromal interactions, and tumor microenvironment remodeling. Clone TFPI2/13028 is designed to detect Placental Protein 5 in research applications and supports investigation of extracellular protease regulation and matrix-associated signaling pathways.
Optimal dilution of the Placental Protein 5/TFPI2 antibody should be determined by the researcher.
A recombinant fragment (around amino acids 100-235) of human TFPI2 protein (exact sequence is proprietary) was used as the immunogen for the Placental Protein 5/TFPI2 antibody.
Placental Protein 5/TFPI2 antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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