- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PLAAT4 Antibody / RARRES3 (FY12877)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12877 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
PLAAT4 antibody detects Phospholipase A and acyltransferase 4, also known as Retinoic acid receptor responder protein 3 (RARRES3), a multifunctional enzyme involved in lipid metabolism, immune regulation, and tumor suppression. Encoded by the PLAAT4 gene on chromosome 11q23.3, this protein belongs to the phospholipase A/acyltransferase family and is induced by retinoic acid signaling. PLAAT4 hydrolyzes membrane phospholipids and transfers acyl chains to form lysophospholipids and neutral lipids, influencing lipid signaling and membrane remodeling.
Structurally, PLAAT4 is an approximately 18 kilodalton enzyme localized to the endoplasmic reticulum and Golgi membranes. It contains a conserved catalytic dyad characteristic of the NlpC/P60 thiol protease superfamily, which mediates both phospholipase A and acyltransferase activities. Through its dual enzymatic function, PLAAT4 regulates cellular lipid composition, affecting membrane curvature, vesicle trafficking, and immune response modulation. Its expression is upregulated by retinoic acid and interferons, suggesting a role in antiviral defense and differentiation control.
The PLAAT4 antibody is widely used in cancer biology, immunology, and lipid signaling research to study retinoid-responsive pathways and lipid remodeling. Western blot analysis identifies a band at approximately 18 kilodaltons corresponding to PLAAT4, while immunofluorescence reveals perinuclear and vesicular localization consistent with endoplasmic reticulum distribution. This antibody enables investigation of how lipid hydrolysis and acylation influence inflammatory signaling and cellular differentiation.
Functionally, PLAAT4 acts as a tumor suppressor by antagonizing the Wnt/beta-catenin pathway, suppressing proliferation, and promoting differentiation in epithelial tissues. It also participates in the interferon-mediated antiviral response, where its enzymatic products help modulate viral replication and immune activation. In lipid metabolism, PLAAT4 contributes to the synthesis of signaling lipids that regulate inflammation and apoptosis. Dysregulation or loss of PLAAT4 expression has been observed in cancers such as breast and colorectal carcinoma, linking it to impaired retinoid signaling and altered lipid homeostasis. The PLAAT4 antibody provides a reliable reagent for exploring these cellular processes and identifying therapeutic targets in retinoid and immune pathways. NSJ Bioreagents validates this antibody for western blotting, immunohistochemistry, and immunofluorescence, ensuring dependable detection in lipid and immune signaling studies.
Optimal dilution of the PLAAT4 antibody should be determined by the researcher.
E.coli-derived human RARRES3/PLAAT4 recombinant protein (Position: M1-K124) was used as the immunogen for the PLAAT4 antibody.
After reconstitution, the PLAAT4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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