- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PKD2 Antibody / Protein kinase D2 (F53969)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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F53969-0.2ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.2 ml | 439 | |
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F53969-0.05ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.05 ml | 205 |
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| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse |
| Predicted Reactivity | Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity |
| UniProt | Q9BZL6 |
| Applications | Western Blot : 1:500-2000 |
| Limitations | This PKD2 Antibody / Protein kinase D2 is available for research use only. |
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PKD2 Antibody recognizes Protein Kinase D2 (PRKD2), a member of the Protein Kinase D family of serine threonine kinases that functions downstream of Protein Kinase C to regulate numerous intracellular signaling pathways. PKD2 is activated by diacylglycerol and phosphorylation events initiated by extracellular stimuli, allowing it to coordinate cell proliferation, survival, migration, secretion, and stress responses. Because of its central role in signal transduction, PKD2 Antibody is widely used to investigate kinase signaling, vesicle trafficking, cardiovascular biology, immune regulation, and cancer.
PKD2 is broadly expressed in mammalian tissues and localizes primarily to the cytoplasm and Golgi apparatus, although activated kinase can also translocate to the nucleus. It regulates Golgi membrane fission, secretory vesicle transport, cytoskeletal organization, and transcriptional responses by phosphorylating numerous downstream substrates. PKD2 also participates in signaling pathways involving Nuclear Factor kappa B (NF-kappa-B), Mitogen-Activated Protein Kinase (MAPK), and histone deacetylases, integrating extracellular signals with changes in gene expression and cellular behavior.
Abnormal PKD2 activity has been associated with several pathological conditions, including breast cancer, prostate cancer, hematologic malignancies, cardiovascular disease, inflammatory disorders, and abnormal angiogenesis. Depending on the cellular context, PKD2 can promote cell survival, proliferation, migration, or resistance to apoptosis, making it an important target for studies of tumor biology and therapeutic intervention. In addition, its roles in endothelial cells, cardiomyocytes, and immune cells continue to expand the understanding of PKD2 function in normal physiology and disease. Consequently, PKD2 Antibody has become an important research tool for studies of kinase signaling and disease mechanisms.
NSJ Bioreagents offers highly validated PKD2 Antibody products for reliable detection of endogenous Protein Kinase D2 in human and animal tissues. These antibodies support investigations into intracellular signaling, vesicle trafficking, kinase regulation, cardiovascular biology, immunology, and oncology while providing dependable performance across western blotting, immunohistochemistry, immunofluorescence, immunoprecipitation, and other research applications.
For additional information on PRKD2 function, signaling pathways and validated research applications, visit our PRKD2 Antibody page.
Titration of the PKD2 Antibody / Protein kinase D2 may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 556-590 from the human protein was used as the immunogen for the PKD2 antibody.
Aliquot the PKD2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
PRKD2 antibody, Protein Kinase D2 antibody, nPKD2 antibody, Serine/Threonine Protein Kinase D2 antibody, Protein Kinase C Mu 2 antibody, PKD2 antibody
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