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Home >> Antibodies >> PKC iota Antibody

PKC iota Antibody (R31734)

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  Catalog No Formulation Size Price (USD)  
Image R31734 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of PKC iota antibody and Lane 1: SHG-44; 2: A549; 3: U87; 4: 293T; 5: HeLa; 6: Jurkat. Predicted/expected size ~68KD
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Western blot testing of PKC iota antibody and Lane 1: SHG-44; 2: A549; 3: U87; 4: 293T; 5: HeLa; 6: Jurkat. Predicted/expected size ~68KD
IHC-P: PKC iota antibody testing of human lung cancer tissue
IHC-P: PKC iota antibody testing of mouse brain tissue
IHC-P: PKC iota antibody testing of rat brain tissue
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Gene ID 5584
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This PKC iota antibody is available for research use only.
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Description

Protein kinase C iota, also called PKCI, is an enzyme that in humans is encoded by the PRKCI gene. This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where it phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. PRKCI is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. It is also a hedgehog target gene that forms a positive feedback loop with GLI and exists at increased levels in basal cell carcinomas.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the PKC iota antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Human partial recombinant protein (AA 21-214) was used as the immunogen for this PKC iota antibody.

Storage

After reconstitution, the PKC iota antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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