- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PKC delta Antibody / PRKCD (R30160)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R30160 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q05655 |
| Localization | Cytoplasm, nucleus, cell membrane |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml |
| Limitations | This PKC delta antibody is available for research use only. |
|
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PKC delta antibody targets Protein kinase C delta, encoded by the PRKCD gene. Protein kinase C delta is a member of the novel PKC subfamily of serine-threonine kinases that are activated by diacylglycerol but function independently of calcium. PKC delta acts as an important intracellular signaling mediator that links extracellular cues to downstream pathways regulating cell growth, differentiation, apoptosis, and stress responses. Under basal conditions, PKC delta is primarily localized in the cytoplasm, but upon activation it translocates to cellular membranes and other subcellular compartments to phosphorylate target substrates.
Functionally, Protein kinase C delta plays a context-dependent role in signal transduction, often acting as a regulator of cell cycle progression and programmed cell death. PKC delta is involved in signaling downstream of growth factor receptors, cytokine receptors, and immune receptors, where it modulates pathways controlling proliferation and survival. In many cellular systems, PKC delta has been associated with pro-apoptotic signaling, particularly in response to DNA damage and oxidative stress, distinguishing it from other PKC isoforms with more pro-survival roles. A PKC delta antibody supports studies focused on kinase signaling and cellular stress response mechanisms.
PRKCD is widely expressed across tissues, with notable expression in hematopoietic cells, epithelial tissues, and the nervous system. In immune cells, PKC delta plays a critical role in regulating B cell activation, tolerance, and signaling thresholds. In epithelial and endothelial cells, PKC delta contributes to regulation of barrier function, migration, and inflammatory responses. Its activity and localization are dynamically regulated by phosphorylation and proteolytic processing, allowing cells to fine-tune signaling outputs in response to changing conditions.
From a disease-relevance perspective, dysregulation of PKC delta signaling has been implicated in cancer, autoimmune disease, and metabolic disorders. Altered PRKCD activity has been reported in hematologic malignancies and solid tumors, where it can influence tumor cell survival, apoptosis, and response to therapy. In the immune system, loss or aberrant regulation of PKC delta has been associated with impaired immune tolerance and autoimmune phenotypes. These findings have made PKC delta an important target in studies of disease-associated signaling imbalance.
At the molecular level, Protein kinase C delta contains conserved regulatory domains that mediate diacylglycerol binding and membrane association, along with a C-terminal kinase domain responsible for catalytic activity. Post-translational modifications and regulated cleavage can influence PKC delta activation state and electrophoretic behavior on SDS-PAGE without indicating changes in primary protein structure. A PKC delta antibody supports research applications focused on intracellular signaling pathways, immune cell biology, and disease-related kinase regulation, with NSJ Bioreagents providing reagents intended for research use.
The stated application concentrations are suggested starting amounts. Titration of the PKC delta antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Human partial recombinant protein (AA 1-160) was used as the immunogen for this PKC delta antibody.
After reconstitution, the PKC delta antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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