- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PICK1 Antibody / Protein interacting with C kinase 1 (FY13119)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13119 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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PICK1 antibody detects Protein interacting with C kinase 1, a scaffolding protein involved in receptor trafficking, synaptic plasticity, and signal transduction. The UniProt recommended name is Protein interacting with C kinase 1 (PICK1). This adaptor protein binds to protein kinase C (PKC) and various membrane receptors to regulate endocytosis and intracellular transport.
Functionally, PICK1 antibody identifies a 415-amino-acid cytoplasmic protein containing a PDZ domain and a BAR domain. The PDZ domain mediates interactions with the C-termini of target proteins such as AMPA-type glutamate receptors, while the BAR domain facilitates membrane curvature sensing and vesicle formation. PICK1 coordinates PKC-dependent receptor internalization and recycling at synapses.
The PICK1 gene is located on chromosome 22q13.1 and is widely expressed in brain, testis, and endocrine tissues. In neurons, PICK1 regulates trafficking of AMPA and metabotropic glutamate receptors, influencing long-term synaptic plasticity. It also interacts with ion channels, transporters, and polarity proteins to maintain signal compartmentalization.
Pathologically, dysregulation of PICK1 contributes to neurological and psychiatric disorders including epilepsy, schizophrenia, and drug addiction. Altered PICK1 expression affects synaptic strength and receptor turnover, disrupting excitatory signaling balance. Research using PICK1 antibody supports studies in synaptic transmission, membrane trafficking, and PKC signaling.
PICK1 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect BAR domain scaffold proteins and synaptic trafficking regulators. NSJ Bioreagents offers PICK1 antibody reagents optimized for neuroscience, receptor biology, and signal transduction research.
Structurally, Protein interacting with C kinase 1 features a PDZ domain that binds short peptide motifs on target proteins and a BAR domain that dimerizes to shape membranes. This antibody enables analysis of PICK1s regulatory function in receptor dynamics and neural signaling.
Optimal dilution of the PICK1 antibody should be determined by the researcher.
E.coli-derived human PICK1 recombinant protein (Position: A41-E376) was used as the immunogen for the PICK1 antibody.
After reconstitution, the PICK1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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