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Home >> Antibodies >> PIAS2 Antibody

PIAS2 Antibody (RQ6001)

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  Catalog No Formulation Size Price (USD)  
Image RQ6001 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Flow cytometry testing of human U937 cells with PIAS2 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= PIAS2 antibody.
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Flow cytometry testing of human U937 cells with PIAS2 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= PIAS2 antibody.
Western blot testing of human 1) K562, 2) HeLa, 3) HepG2, 4) HEK293, 5) HL-60, 6) Raji, 7) A431, 8) rat brain, 9) rat C6, 10) mouse brain, 11) mouse testis, 12) mouse Neuro-2a and 13) mouse RAW264.7 lysate with PIAS2 antibody. Predicted molecular weight: ~63 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
UniProt O75928
Applications Western blot : 0.5-1ug/ml
Flow cytometry : 1-3ug/million cells
Direct ELISA : 0.1-0.5ug/ml
Limitations This PIAS2 antibody is available for research use only.
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Description

E3 SUMO-protein ligase PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene. It is mapped to 18q21.1. This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.

Application Notes

Optimal dilution of the PIAS2 antibody should be determined by the researcher.

Immunogen

Recombinant human protein (amino acids E93-K311) was used as the immunogen for the PIAS2 antibody.

Storage

After reconstitution, the PIAS2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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