- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Phospholipase A2 Antibody / PLA2G4A / cPLA2 (F54970)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F54970-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 399 | |
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F54970-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 185 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity purified |
| UniProt | P47712 |
| Localization | Cytoplasmic, nuclear |
| Applications | Western blot : 1:500-1:1000 Flow cytometry : 1:10-1:50 (1x10e6 cells) Immunofluorescence : 1:10-1:50 Immunohistochemistry (FFPE) : 1:10-1:50 |
| Limitations | This Phospholipase A2 antibody is available for research use only. |
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PLA2G4A is a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
The stated application concentrations are suggested starting points. Titration of the Phospholipase A2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 513-541 from the human protein was used as the immunogen for the Phospholipase A2 antibody.
Aliquot the Phospholipase A2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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