- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Phospho-VASP (Ser156) Antibody / Vasodilator-stimulated phosphoprotein [clone 32V43] (FY12271)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12271 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 439 |
|
| Availability | 2-3 weeks |
| Species Reactivity | Human |
| Format | Liquid |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | 32V43 |
| Purity | Affinity-chromatography |
| Buffer | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| UniProt | P50552 |
| Applications | Western Blot : 1:500-1:2000 Immunohistochemistry : 1:50-1:200 |
| Limitations | This Phospho-VASP (Ser156) antibody is available for research use only. |
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Phospho-VASP (Ser156) antibody is designed to recognize vasodilator-stimulated phosphoprotein (VASP) when phosphorylated at the serine 156 residue. VASP is a member of the Ena/VASP protein family, which plays a central role in regulating actin cytoskeleton dynamics. This protein localizes to focal adhesions, lamellipodia, and filopodia, where it contributes to actin filament elongation and cell motility. Phosphorylation of VASP at serine 156 by protein kinase A (PKA) or protein kinase G (PKG) reduces its ability to bind actin filaments and modulates cytoskeletal remodeling, thereby influencing cell adhesion and migration.
Phospho-VASP (Ser156) antibody is widely used to study endothelial cell signaling, vascular tone regulation, and platelet activation. VASP phosphorylation is often used as a biomarker for nitric oxide and cGMP-dependent signaling pathways, making this antibody highly relevant for cardiovascular and vascular biology research. In platelets, phosphorylation at serine 156 is associated with inhibition of platelet aggregation, linking this protein to thrombotic and hemostatic processes.
This antibody provides specificity for the phosphorylated serine 156 residue, allowing researchers to distinguish activated signaling states from total VASP levels. It has proven valuable in applications such as western blot, immunohistochemistry, immunofluorescence, and flow cytometry, where phosphorylation-dependent changes in protein activity are key to understanding cellular responses.
Beyond vascular biology, VASP phosphorylation is also studied in cancer research. Altered cytoskeletal regulation contributes to tumor cell invasion and metastasis, and VASP activity is linked to actin-driven protrusions in malignant cells. Monitoring phosphorylation states using phospho-specific antibodies allows scientists to assess signaling cascades that contribute to disease progression.
Phospho-VASP (Ser156) antibody is a reliable reagent for dissecting nitric oxide-mediated signaling and cytoskeletal control. Its specificity for phosphorylation status ensures that researchers can accurately track pathway activation in different cellular contexts. NSJ Bioreagents offers this antibody for investigators focused on cardiovascular biology, oncology, and platelet research.
Optimal dilution of the Phospho-VASP (Ser156) antibody should be determined by the researcher.
A synthesized peptide derived from human Phospho-VASP (S156) was used as the immunogen for the Phospho-VASP (Ser156) antibody.
Store the Phospho-VASP (Ser156) antibody at -20oC.
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