- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Phospho-Tau (Ser198) Antibody / MAPT [clone 31M15] (FY12053)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12053 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 439 |
| Availability | 2-3 weeks |
| Species Reactivity | Human, Mouse, Rat |
| Format | Liquid |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | 31M15 |
| Purity | Affinity-chromatography |
| Buffer | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| UniProt | P10636 |
| Applications | Western Blot : 1:500-1:2000 Immunohistochemistry : 1:50-1:200 Immunoprecipitation : 1:50 |
| Limitations | This Phospho-Tau (Ser198) antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Phospho-Tau (Ser198) antibody detects tau protein (MAPT) phosphorylated at serine 198, a modification associated with cytoskeletal regulation and neurodegeneration. Tau stabilizes microtubules in neurons, but abnormal phosphorylation weakens this interaction and promotes aggregation into neurofibrillary tangles, a hallmark of Alzheimer's disease and related tauopathies.
Research with Phospho-Tau (Ser198) antibody shows that phosphorylation at Ser198 occurs early in tau pathology and may precede other modifications. This residue is phosphorylated by kinases such as GSK-3beta and CDK5, linking it to pathways commonly dysregulated in Alzheimer's disease. Monitoring Ser198 phosphorylation provides insight into the progression of tau-driven neuronal dysfunction.
Antibodies specific for phospho-tau (Ser198) are validated for applications including western blot, immunohistochemistry, and immunofluorescence. These tools allow selective detection of phosphorylated tau, supporting studies of biomarker development and therapeutic strategies.
NSJ Bioreagents supplies this Phospho-Tau (Ser198) antibody for neurodegeneration and signal transduction research.
Optimal dilution of the Phospho-Tau (Ser198) antibody should be determined by the researcher.
A synthesized peptide derived from human Phospho-Tau (S198) was used as the immunogen for the Phospho-Tau (Ser198) antibody.
Store the Phospho-Tau (Ser198) antibody at -20oC.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
