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Home >> Antibodies >> Phospho-Tau Antibody (pS396)

Phospho-Tau Antibody (pS396) [clone FCO-13] (RQ5330)

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Image RQ5330 Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA 100 ul 429
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Western blot testing of 1) lysate from alkaline phosphatase-treated SH-SY5Y cells and 2) lysate from untreated SH-SY5Y cells, with phospho-Tau antibody (pS396). The S396 site is naturally highly phosphorylated and negative testing results after phosphatase treatment demonstrates the specificity of the phospho-Tau antibody. Expected molecular weight: 50-80 kDa.
Western blot testing of 1) lysate from alkaline phosphatase-treated SH-SY5Y cells and 2) lysate from untreated SH-SY5Y cells, with phospho-Tau antibody (pS396). The S396 site is naturally highly phosphorylated and negative testing results after phosphatase treatment demonstrates the specificity of the phospho-Tau antibody. Expected molecular weight: 50-80 kDa.
Availability 1-2 weeks
Species Reactivity Human
Format Purified
Clonality Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name FCO-13
Purity Affinity purified
UniProt P10636
Applications Western blot : 1:10000-1:20000
Limitations This phospho-Tau antibody (pS396) is available for research use only.
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Description

Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. Pathologies and dementias of the nervous system such as Alzheimer's disease and Parkinson's disease are associated with tau proteins that have become defective and no longer stabilize microtubules properly.

Tau is a phosphoprotein with 79 potential Serine (Ser) and Threonine (Thr) phosphorylation sites on the longest tau isoform. Phosphorylation has been reported on approximately 30 of these sites in normal tau proteins. Phosphorylation of tau is regulated by a host of kinases, including PKN, a serine/threonine kinase. When PKN is activated, it phosphorylates tau, resulting in disruption of microtubule organization. Phosphorylation of tau is also developmentally regulated. For example, fetal tau is more highly phosphorylated in the embryonic CNS than adult tau. [Wiki]

Application Notes

Optimal dilution of the phospho-Tau antibody (pS396) should be determined by the researcher.

Immunogen

A synthetic peptide specific to human Tau / MAPT (surrounding pS396) was used as the immunogen for the phospho-Tau antibody.

Storage

Store the phospho-Tau antibody (pS396) at -20oC.

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