- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Phospho-RPA32 Antibody (pT21) [clone FCG-18] (RQ5458)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
RQ5458 | Antibody in PBS with 0.02% sodium azide and 50% glycerol | 100 ul | 429 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | FCG-18 |
| Purity | Affinity purified |
| UniProt | P15927 |
| Applications | Western blot : 1:5000-1:10000 |
| Limitations | This phospho-RPA32 antibody (pT21) is available for research use only. |
|
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The RPA2 gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [RefSeq]
Optimal dilution of the phospho-RPA32 antibody (pT21) should be determined by the researcher.
A synthetic peptide specific to human RPA32 (surrounding pT21) was used as the immunogen for the phospho-RPA32 antibody.
Store the phospho-RPA32 antibody (pT21) at -20oC.
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