- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PTEN (pY315) Antibody / Phospho-PTEN Tyr315 Antibody (F48805)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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F48805-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 439 | |
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F48805-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 205 |
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| Availability | 1-3 business days |
| Species Reactivity | Human |
| Predicted Reactivity | Mouse |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity |
| UniProt | P60484 |
| Applications | Dot Blot : 1:500 |
| Limitations | This PTEN (pY315) Antibody / Phospho-PTEN Tyr315 Antibody is available for research use only. |
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PTEN (pY315) Antibody / Phospho-PTEN Tyr315 Antibody recognizes PTEN when phosphorylated at tyrosine 315. PTEN, or phosphatase and tensin homolog, is a major tumor suppressor and negative regulator of phosphoinositide 3-kinase (PI3K)/AKT signaling. Through its lipid phosphatase activity, PTEN converts phosphatidylinositol (3,4,5)-trisphosphate (PIP3) to phosphatidylinositol (4,5)-bisphosphate (PIP2), opposing PI3K activity and limiting downstream signals involved in cellular proliferation, survival, growth and metabolism.
PTEN function is regulated through multiple post-translational modifications, including phosphorylation at serine, threonine and tyrosine residues. These modifications can influence protein stability, catalytic activity, subcellular localization and interactions with other cellular proteins. Tyr315 is located within the C2 domain of PTEN, a region that contributes to membrane association and the positioning of PTEN relative to its membrane-associated substrates. A PTEN (pY315) Antibody enables investigation of this site-specific phosphorylated form independently of total PTEN expression.
Tyrosine phosphorylation can provide an important mechanism for integrating PTEN into cellular signaling networks. Changes in the phosphorylation state of individual residues may influence PTEN interactions or functional properties without necessarily altering overall protein abundance. Studying Tyr315 phosphorylation can therefore complement measurements of total PTEN and provide additional information about phosphorylation-dependent regulation of this tumor suppressor.
PTEN is frequently altered in human cancers through mutation, deletion, reduced expression or disruption of mechanisms controlling its activity. Impaired PTEN function can result in increased PI3K/AKT signaling and contribute to abnormal cell proliferation and survival. Phospho-specific analysis allows researchers to examine regulatory changes in PTEN that may occur even when total PTEN remains detectable, providing another approach to studying PTEN signaling in cancer and other disease models.
Researchers studying phosphorylation-dependent regulation of PTEN and related signaling proteins can explore our Phospho Antibody - Phosphorylation Specific Antibodies page for additional reagents targeting site-specific phosphorylation events involved in signal transduction, growth regulation and disease biology.
NSJ Bioreagents offers PTEN (pY315) Antibody for research into site-specific phosphorylation and PTEN signaling. A Phospho-PTEN Tyr315 Antibody can support studies of PTEN regulation, PI3K/AKT signaling, tumor suppressor biology and cellular mechanisms involving phosphorylation-dependent signaling.
For broader research into PTEN expression and tumor suppressor function, explore our PTEN Antibody page for additional reagents targeting phosphatase and tensin homolog.
Titration of the PTEN (pY315) Antibody / Phospho-PTEN Tyr315 Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This PTEN (pY315) Antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY315 of human PTEN.
Aliquot the PTEN (pY315) Antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
PTEN (pY315) antibody, Phospho-PTEN Tyr315 antibody, PTEN phospho-Tyr315 antibody, PTEN pTyr315 antibody, PTEN Tyr315 antibody, Phosphatase and Tensin Homolog antibody
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