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Home >> Antibodies >> Phospho-IKKB Antibody (pT180)

Phospho-IKKB Antibody (pT180) (F48798)

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  Catalog No Formulation Size Price (USD)  
Image F48798-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F48798-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Dot blot analysis of phospho-IKKB antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.
Dot blot analysis of phospho-IKKB antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Bovine, Chicken, Mouse, Rat, Xenopus, Zebrafish
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt O14920
Applications Dot blot : 1:500
Limitations This phospho-IKKB antibody is available for research use only.
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Description

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).

Application Notes

Titration of the phospho-IKKB antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This phospho-IKKB antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT180 of human IKKB.

Storage

Aliquot the phospho-IKKB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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