- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Yeast Phospho-Histone H2A Antibody pS129 / DNA Damage Response Chromatin Antibody [clone DEE-8] (RQ5093)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ5093 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 449 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Yeast |
| Format | Purified |
| Host | Rabbit |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | DEE-8 |
| Purity | Affinity purified |
| UniProt | P04912 |
| Applications | Western Blot : 1:1000-1:2000 |
| Limitations | This Phospho-Histone H2A antibody (pS129) is available for research use only. |
|
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Phosphorylation of histone H2A at serine 129 in yeast represents a fundamental chromatin-based signaling event in response to DNA damage. Yeast Phospho-Histone H2A Antibody pS129 / DNA Damage Response Chromatin Antibody (clone DEE-8) is designed to detect Histone H2A phosphorylated at serine 129, providing a highly specific marker of DNA damage-associated chromatin remodeling. Included within the Histone H2A antibodies collection, this antibody enables analysis of histone modification patterns and chromatin regulatory mechanisms involving H2A and its variants.
HIST1H2A antibody, also referred to as Histone H2A antibody and H2A pS129 antibody in the literature, recognizes a modification functionally analogous to gamma-H2AX phosphorylation in mammalian systems. This phosphorylation occurs rapidly following DNA double-strand breaks and serves as a critical signal for recruitment of DNA repair machinery.
This recombinant rabbit monoclonal clone DEE-8 antibody is uniquely positioned for studies of DNA damage signaling and genome stability. Upon DNA damage, phosphorylation at Ser129 spreads over large chromatin domains surrounding the lesion, forming signaling platforms that coordinate repair processes.
At the molecular level, H2A Ser129 phosphorylation facilitates recruitment of key DNA repair factors, including checkpoint proteins and chromatin remodeling complexes. It promotes chromatin relaxation, allowing access to damaged DNA and enabling efficient repair.
This modification plays a central role in maintaining genome integrity and is widely used as a marker of DNA damage in yeast systems. Its presence reflects activation of DNA damage response pathways rather than transcriptional regulation.
Unlike acetylation and methylation marks, which primarily regulate gene expression, phosphorylation at Ser129 is directly linked to cellular stress responses and DNA repair. It represents a rapid and reversible modification that signals genome instability.
At the cellular level, H2A Ser129 phosphorylation localizes to the nucleus and often forms distinct foci at sites of DNA damage. These foci correspond to regions where repair complexes accumulate and function.
This antibody supports detection of Ser129-phosphorylated Histone H2A, enabling investigation of DNA damage response, chromatin repair mechanisms, and cellular responses to genotoxic stress.
Optimal dilution of the Yeast Phospho-Histone H2A Antibody pS129 / DNA Damage Response Chromatin Antibody should be determined by the researcher.
A synthetic peptide specific to yeast Histone H2A (surrounding pS129) was used as the immunogen for the Yeast Phospho-Histone H2A Antibody pS129 / DNA Damage Response Chromatin Antibody.
Store the Phospho-Histone H2A antibody (pS129) at -20oC.
Histone H2A Ser129 phosphorylation antibody, yeast gamma-H2A antibody, H2A pS129 DNA damage antibody, phospho histone H2A Ser129 antibody
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