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- Tel: 858.663.9055
- Email: info@nsjbio.com
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CRK is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.
Titration of the phospho-CRK antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This phospho-CRK antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS41 of human CRK.
Aliquot the phospho-CRK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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