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- Tel: 858.663.9055
- Email: info@nsjbio.com
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c-Myc participates in the regulation of gene transcription. It binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. This protein appears to activate the transcription of growth-related genes. Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia.
Titration of the phospho c-Myc antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This phospho c-Myc antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT58 of human MYC.
Aliquot the phospho c-Myc antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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