- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Phospho-B Raf Antibody (pT401) [clone IBE-2] (RQ5439)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
RQ5439 | Antibody in PBS with 0.02% sodium azide and 50% glycerol | 100 ul | 429 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Human, Mouse, Rat |
| Format | Purified |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | IBE-2 |
| Purity | Affinity purified |
| UniProt | P15056 |
| Applications | Western blot : 1:500-1:2000 |
| Limitations | This phospho-B Raf antibody (pT401) is available for research use only. |
|
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The BRAF gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. [RefSeq]
Optimal dilution of the phospho-B Raf antibody (pT401) should be determined by the researcher.
A synthetic peptide specific to human B Raf (surrounding pT401) was used as the immunogen for the phospho-B Raf antibody.
Store the phospho-B Raf antibody (pT401) at -20oC.
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