PHF8 Antibody / PHD finger protein 8 [clone ADAI-16] (RQ8907)

Description

PHD finger protein 8 (PHF8) is a histone demethylase that specifically removes methyl groups from lysine residues on histone H3, including H3K9me2 and H3K27me2. By altering chromatin structure, PHF8 regulates transcriptional activation and repression, influencing processes such as cell cycle progression, neuronal development, and differentiation.

PHF8 contains a PHD finger domain that recognizes specific histone modifications, allowing it to target distinct genomic loci. Mutations in PHF8 have been associated with X-linked intellectual disability and craniofacial anomalies. Research on PHF8 provides valuable insights into epigenetic regulation, development, and disease mechanisms.

Using a high-quality PHF8 antibody enables precise detection in applications such as western blot, immunohistochemistry, and chromatin immunoprecipitation. A PHF8 antibody from NSJ Bioreagents ensures reproducibility and sensitivity for studies in epigenetics, transcriptional regulation, and developmental biology. Selecting the right PHF8 antibody is essential for generating consistent and meaningful results.

Application Notes

Optimal dilution of the PHF8 antibody should be determined by the researcher.

Immunogen

A peptide sequence specific to PHD finger protein 8 protein was used as the immunogen for the PHF8 antibody.

Storage

After reconstitution, the PHF8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.