- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PEX11B Antibody / Peroxisomal membrane protein 11B [clone 29P66] (FY12824)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12824 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 439 |
PEX11B antibody detects PEX11B, a peroxisomal biogenesis factor encoded by the PEX11B gene. Other names include peroxisomal membrane protein 11B and PMP11B. PEX11B is a peroxisomal membrane protein that regulates peroxisome proliferation and division. It belongs to the PEX11 family, which control peroxisome number and morphology. PEX11B promotes peroxisomal elongation, constriction, and fission, ensuring proper distribution of peroxisomes during cell division and differentiation. Peroxisomes are essential organelles involved in lipid metabolism, reactive oxygen species detoxification, and bile acid synthesis, making PEX11B critical for cellular homeostasis.
PEX11B antibody is widely applied in cell biology, metabolism, and disease research. By detecting PEX11B, researchers can explore how peroxisomes multiply and adapt to metabolic demands. Knockout studies show that PEX11B deficiency leads to reduced peroxisome number, altered lipid metabolism, and developmental abnormalities. This highlights its importance in peroxisome biogenesis disorders.
Applications include western blotting, immunohistochemistry, immunofluorescence, and ELISA. Western blotting identifies PEX11B protein in peroxisome enriched fractions, immunohistochemistry maps tissue distribution in liver and kidney, and immunofluorescence highlights peroxisomal membranes. These assays provide robust tools for evaluating peroxisome biology in health and disease.
Mutations in PEX11B cause peroxisome biogenesis disorders characterized by cataracts, intellectual disability, and developmental delay. These disorders illustrate the essential role of PEX11B in organelle maintenance. By applying PEX11B antibody, scientists can investigate peroxisomal dynamics, inheritance, and disease mechanisms. In addition, altered peroxisome function is linked to metabolic syndromes, cancer, and neurodegeneration, making PEX11B relevant beyond rare genetic disease.
PEX11B interacts with dynamin like proteins and other peroxisome fission factors, coordinating peroxisome proliferation with mitochondrial dynamics. This crosstalk underscores its importance in cellular energy balance. NSJ Bioreagents provides PEX11B antibody with strong specificity, supporting accurate detection of this essential peroxisomal protein in both basic and translational studies.
Optimal dilution of the PEX11B antibody should be determined by the researcher.
A synthesized peptide derived from human PEX11B was used as the immunogen for the PEX11B antibody.
Store the PEX11B antibody at -20oC.
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