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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Periostin Antibody Rabbit Polyclonal / POSTN (R32897)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R32897 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide |
| UniProt | D3ZAF5 |
| Localization | Cytoplasm, extracellular space |
| Applications | Western Blot : 0.5-1ug/ml IHC (FFPE) : 1-2ug/ml Direct ELISA (recombinant Rat Protein) : 0.1-0.5ug/ml (BSA-free format available) |
| Limitations | This Periostin antibody is available for research use only. |
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Periostin antibody recognizes Periostin, a secreted extracellular matrix protein encoded by the POSTN gene and also referred to as osteoblast specific factor 2 in the literature. Periostin Antibody Rabbit Polyclonal is designed for research applications focused on detecting this matricellular protein within stromal and connective tissue compartments. Periostin is synthesized as a secreted protein that localizes to the extracellular matrix, where it interacts with integrins and structural matrix components to influence tissue remodeling and cell adhesion.
Periostin antibody, also known as POSTN antibody and osteoblast specific factor 2 antibody, targets a member of the fasciclin family of proteins. Structurally, Periostin contains an N-terminal signal peptide, a cysteine-rich EMI domain, four tandem fasciclin-like domains, and a C-terminal region subject to alternative splicing. These domains mediate interactions with integrins such as alpha v beta 3 and alpha v beta 5, as well as with collagen and fibronectin, contributing to matrix organization and mechanical stability in connective tissues.
POSTN expression is prominent in periosteum, periodontal ligament, heart valves, and other mechanically stressed tissues. It is induced during wound healing, fibrosis, and inflammatory responses, where it promotes fibroblast activation, collagen fibrillogenesis, and tissue repair. In the cardiovascular system, Periostin supports valvular development and remodeling, while in bone it participates in osteoblast differentiation and matrix deposition.
In oncology research, Periostin has been studied as a stromal marker associated with tumor progression, epithelial-mesenchymal transition, and metastatic potential. Elevated POSTN expression has been reported in breast, lung, colon, and pancreatic cancers, often localized to cancer-associated fibroblasts and tumor stroma rather than malignant epithelial cells themselves. This distribution pattern makes Periostin antibody useful for investigating tumor microenvironment biology and stromal-epithelial interactions.
The rabbit polyclonal Periostin antibody provides broad epitope recognition across the Periostin protein, supporting detection of endogenous POSTN in tissue sections and cell-based assays. Its extracellular localization and involvement in matrix remodeling pathways make it a valuable tool for studies of fibrosis, development, and cancer-associated stroma at NSJ Bioreagents.
Optimal dilution of the Periostin antibody rabbit polyclonal should be determined by the researcher.
A recombinant rat protein corresponding to amino acids K577-Q810 was used as the immunogen for the Periostin antibody rabbit polyclonal.
After reconstitution, the Periostin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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