- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Periostin Antibody / POSTN [clone POSTN/8951R] (V4315)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4315-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4315-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
|
V4315SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | POSTN/8951R |
| Purity | Protein A/G affinity |
| UniProt | Q15063 |
| Localization | Secreted, Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT Western Blot : 2-4ug/ml |
| Limitations | This Periostin antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Periostin (POSTN) is a secreted extracellular matrix glycoprotein that plays a central role in tissue remodeling, cell adhesion, and extracellular matrix organization. Periostin (POSTN) is also known as osteoblast specific factor 2 and is widely expressed in connective tissues, particularly in areas undergoing active remodeling or mechanical stress. Periostin Antibody / POSTN is useful for detecting this stromal-associated protein in studies focused on fibrosis, tumor microenvironment dynamics, and tissue repair processes. POSTN is prominently expressed in fibroblasts and stromal cells and is enriched in tissues such as periosteum, heart, lung, and kidney, where it contributes to structural integrity and cellular signaling.
Periostin antibody, also referred to as POSTN antibody or osteoblast specific factor 2 antibody, recognizes a matricellular protein that interacts with integrins and other extracellular matrix components to regulate cell adhesion, migration, and survival. POSTN contains fasciclin-like domains that mediate binding to integrins such as alpha v beta 3 and alpha v beta 5, facilitating activation of downstream signaling pathways involved in cell motility and extracellular matrix deposition. As a secreted protein, periostin is deposited into the extracellular matrix, where it contributes to the organization and stabilization of collagen-rich networks and supports tissue architecture.
POSTN expression is strongly induced during wound healing, fibrosis, and tumor progression, where it plays a key role in extracellular matrix remodeling and stromal activation. In fibrotic diseases, elevated periostin levels contribute to excessive matrix deposition and increased tissue stiffness. In cancer, POSTN is frequently upregulated in tumor-associated stroma and has been linked to enhanced tumor growth, invasion, and metastatic potential. Its expression is often associated with activated fibroblasts and desmoplastic reactions, making it a valuable marker for studying stromal biology and tumor microenvironment interactions.
Periostin also participates in signaling pathways that regulate cell survival and differentiation, particularly through interactions with integrin receptors and activation of pathways such as PI3K/AKT and focal adhesion kinase signaling. These pathways contribute to cell proliferation, migration, and resistance to apoptosis, highlighting the importance of POSTN in both normal tissue maintenance and disease processes. Its role in mechanotransduction further links it to tissues subjected to mechanical stress, including cardiovascular and skeletal systems.
Given its strong association with extracellular matrix remodeling, fibrosis, and tumor-associated stroma, POSTN is an important target for investigating connective tissue biology and disease progression. A Periostin antibody can be used in western blot, immunohistochemistry, or other research assays to evaluate POSTN expression in tissue samples and experimental models, supporting studies in fibrosis, cancer biology, and extracellular matrix signaling.
This antibody is part of a broader antibody panel offered by NSJ Bioreagents.
Optimal dilution of the Periostin antibody should be determined by the researcher.
A recombinant fragment of human POSTN protein was used as the immunogen for the Periostin antibody.
Aliquot the Periostin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Periostin antibody, POSTN antibody, Osteoblast specific factor 2 antibody, OSF-2 antibody, PN antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
