- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PECAM-1 Antibody / CD31 [clone C31/8593R] (V4543)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4543-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4543-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V4543SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | C31/8593R |
| Purity | Protein A/G affinity |
| UniProt | P16284 |
| Localization | Cell Surface, Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This PECAM-1 antibody is available for research use only. |
|
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PECAM-1 antibody recognizes CD31, a junctional adhesion receptor widely expressed on vascular endothelial cells and hematopoietic lineages. The protein is encoded by the PECAM1 gene and is primarily localized to the cell membrane at endothelial cell-cell contacts. CD31 is considered a canonical endothelial marker because of its strong and consistent expression in vascular linings throughout adult tissues.
Functionally, PECAM-1 regulates endothelial barrier integrity and mediates leukocyte passage from the bloodstream into surrounding tissues. Through homophilic binding interactions, it maintains endothelial cohesion while simultaneously enabling controlled transmigration during immune responses. CD31 antibody is frequently used to evaluate vascular density, identify endothelial differentiation, and assess tumor vascularization in research settings.
At the molecular level, PECAM-1 is composed of extracellular immunoglobulin-like domains that facilitate adhesion and intracellular signaling motifs that modulate downstream phosphatase recruitment. These features allow PECAM-1 to participate in integrin signaling and mechanotransduction pathways that respond to shear stress within blood vessels. The protein is also involved in platelet-endothelial interactions and contributes to thromboregulatory mechanisms.
Altered PECAM-1 expression patterns are associated with inflammatory disorders, vascular injury, and malignancy-associated angiogenesis. Because CD31 expression is concentrated in vascular endothelium, it serves as a reliable tool for studying microvascular architecture and endothelial activation. PECAM-1 antibody supports research applications examining vascular development, inflammation, and tumor biology.
Optimal dilution of the PECAM-1 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 538-738) from the human protein was used as the immunogen for the PECAM-1 antibody.
Aliquot the PECAM-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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