- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PECAM-1 Antibody / CD31 [clone C31/8828R] (V4544)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4544-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V4544-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4544SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | C31/8828R |
| Purity | Protein A/G affinity |
| UniProt | P16284 |
| Localization | Cell Surface, Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This PECAM-1 antibody is available for research use only. |
|
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PECAM-1 antibody, also known as CD31 antibody, recognizes Platelet endothelial cell adhesion molecule 1, a transmembrane glycoprotein of the immunoglobulin superfamily encoded by the PECAM1 gene on chromosome 17q23.3. PECAM-1 is predominantly localized to the plasma membrane of endothelial cells, where it concentrates at intercellular junctions. It is also expressed on platelets, monocytes, neutrophils, and certain lymphocyte subsets. In vascular tissues, PECAM-1 functions as a key structural and signaling component of endothelial junctional complexes.
PECAM-1 mediates homophilic adhesion between adjacent endothelial cells and plays a central role in leukocyte transmigration across the vascular endothelium. During inflammation, PECAM-1 facilitates diapedesis by guiding leukocytes through endothelial junctions. CD31 antibody is widely used in vascular biology and pathology research as a marker of endothelial cells and angiogenesis. Its membranous localization pattern makes it especially useful for highlighting microvessel density in tumor specimens.
Structurally, PECAM-1 contains six extracellular immunoglobulin-like domains, a single transmembrane region, and a cytoplasmic tail with immunoreceptor tyrosine-based inhibitory motifs. These motifs participate in intracellular signaling events that regulate cell survival, migration, and cytoskeletal organization. PECAM-1 integrates signals from mechanical shear stress and inflammatory stimuli, contributing to vascular homeostasis.
Dysregulation of PECAM1 expression has been implicated in vascular inflammation, atherosclerosis, thrombosis, and tumor-associated angiogenesis. Increased endothelial expression often correlates with neovascularization in malignant tissues. A PECAM-1 antibody is suitable for detecting CD31 expression in research applications focused on endothelial biology and vascular remodeling.
Optimal dilution of the PECAM-1 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 538-738) from the human protein was used as the immunogen for the PECAM-1 antibody.
Aliquot the PECAM-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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