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Home >> Antibodies >> PDX1 Antibody / Pancreas/duodenum homeobox protein 1

PDX1 Antibody / Pancreas/duodenum homeobox protein 1 (F52924)

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  Catalog No Formulation Size Price (USD)  
Image F52924-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F52924-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot analysis of lysate from 1) mouse pancreas and 2) rat pancreas tissue using PDX1 antibody at 1:1000. Observed molecular weight 31/40~46kDa (unmodified/modified).
Western blot analysis of lysate from 1) mouse pancreas and 2) rat pancreas tissue using PDX1 antibody at 1:1000. Observed molecular weight 31/40~46kDa (unmodified/modified).
Availability 1-3 business days
Species Reactivity Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P52945
Applications Western blot : 1:1000
Limitations This PDX1 antibody is available for research use only.
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Description

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

Application Notes

Titration of the PDX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This PDX1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 21-55 amino acids from the N-terminal region of human Pancreas/duodenum homeobox protein 1.

Storage

Aliquot the PDX1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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