- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PD1 Antibody / PDCD1 [clone RMP1-14] (V8347)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
V8347-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 519 | |
|
|
V8347-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 229 | |
|
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V8347SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 519 |
|
| Availability | 1-3 business days |
| Species Reactivity | Mouse |
| Format | Purified |
| Clonality | Monoclonal (rat origin) |
| Isotype | Rat IgG2a, kappa |
| Clone Name | RMP1-14 |
| Purity | Protein G affinity chromatography |
| UniProt | Q02242 |
| Applications | ELISA (order BSA/azide-free format for coating) : Neutralization Studies (order BSA/azide-free format) : Flow cytometry : 1-2ug/10^6 cells in 0.1ml Immunofluorescence : 0.5-1ug/ml |
| Limitations | This PD1 antibody is available for research use only. |
|
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PD-1 is expressed on a subset of CD4-CD8-thymocytes, and on activated T and B cells. PD-1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B-lymphocytes and myeloid cells. Additionally, Pdcd1 mRNA is expressed in developing B-lymphocytes during the pro-B-cell stage. The RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production co-stimulated by macrophages (but not by dendritic cells and B cells).
Optimal dilution of the PD1 antibody should be determined by the researcher.
PDCD1 transfected BHK cells were used as the immunogen for the PD1 antibody.
Store the PD1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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