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Home >> Antibodies >> PD-L1 Antibody / B7-H1 / CD274

PD-L1 Antibody / B7-H1 / CD274 [clone PDL1/2744] (V7988)

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  Catalog No Formulation Size Price (USD)  
Image V7988-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V7988-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V7988SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Western blot testing of human and mouse samples with PD-L1 antibody (clone PDL1/2744). Predicted molecular weight ~34 kDa (unmodified), 45-70 kDa (glycosylated).
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Western blot testing of human and mouse samples with PD-L1 antibody (clone PDL1/2744). Predicted molecular weight ~34 kDa (unmodified), 45-70 kDa (glycosylated).
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using PD-L1 antibody (clone PDL1/2744). These results demonstrate the foremost specificity of the PDL1/2744 mAb.
Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
SDS-PAGE analysis of purified, BSA-free PD-L1 antibody (clone PDL1/2744) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name PDL1/2744
Purity Protein G affinity chromatography
UniProt Q9NZQ7
Localization Cell surface, cytoplasmic
Applications ELISA (order BSA-free format for coating) :
Western blot : 1-2ug/ml
Limitations This PD-L1 antibody is available for research use only.
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Description

Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T-cell proliferation, cytokine production, differentiation of effector T-cells and the induction of BCLX, a promoter of T-cell survival. Engagement of CTLA4 by B7-1 or B7-2, on the other hand, may inhibit proliferation and interleukin-2 (IL-2) production. PD-L1 is 290-amino acid type I transmembrane protein, which is 20% and 15% identical to B7-1 and B7-2, respectively, has immunoglobulin V-like and C-like domains and a 30-amino acid cytoplasmic tail. PD-L1 does not bind CD28, cytotoxic T-lymphocyte A4 or ICOS (inducible co-stimulator). IL-2, although produced in small amounts, is required for the effect of PD-L1 co-stimulation. PD-L2 protein contains a signal sequence, IgV- and IgC-like domains, a transmembrane region and a cytoplasmic region. The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the PD-1-PD-L system could provide unique negative signaling to help prevent autoimmune diseases.

Application Notes

Optimal dilution of the PD-L1 antibody should be determined by the researcher.

Immunogen

A recombinant human partial protein (amino acids 39-191) was used as the immunogen for the PD-L1 antibody.

Storage

Store the PD-L1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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