- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PD-L1 Antibody - Microarray Validated / B7-H1 / CD274 [clone PDL1/2745] (V8009)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8009-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V8009-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8009SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | PDL1/2745 |
| Purity | Protein G affinity chromatography |
| UniProt | Q9NZQ7 |
| Localization | Cell surface, cytoplasmic |
| Applications | ELISA (order BSA-free Format For Coating) : |
| Limitations | This PD-L1 antibody is available for research use only. |
|
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Programmed death-ligand 1 (PD-L1), encoded by the CD274 gene, is an immune checkpoint ligand that plays a central role in regulating T cell responses and maintaining immune tolerance. PD-L1 Antibody Microarray Validated targets this transmembrane immunoregulatory protein, which is widely referred to in the literature as PD-L1, CD274, or B7-H1. PD-L1 belongs to the B7 family of immune regulatory molecules and functions primarily through interaction with the inhibitory receptor PD-1 expressed on activated T lymphocytes. Because of this biology, PD-L1 antibody detection is widely used in research examining immune checkpoint signaling, tumor immune evasion, and immune regulation within epithelial and immune cell populations.
The PD-1/PD-L1 signaling pathway is a key mechanism for maintaining immune homeostasis. Binding of PD-L1 to PD-1 transmits inhibitory signals that reduce T cell proliferation, cytokine production, and cytotoxic activity, thereby limiting immune responses and preventing excessive immune activation. While this pathway normally protects tissues from immune-mediated damage, many tumors exploit the checkpoint mechanism by increasing PD-L1 expression on tumor cells and tumor-associated immune cells. Elevated PD-L1 expression suppresses anti-tumor immune responses and allows malignant cells to evade immune surveillance. For this reason, CD274 antibody reagents are frequently used in studies investigating tumor immunology, immune checkpoint biology, and inflammatory signaling pathways.
The CD274 gene is located on chromosome 9p24.1 and encodes a type I transmembrane glycoprotein containing extracellular immunoglobulin-like domains typical of B7 family proteins. PD-L1 expression is normally detected on antigen-presenting cells including dendritic cells and macrophages, as well as on certain epithelial and endothelial cell populations. Expression can be strongly induced by inflammatory cytokines, particularly interferon-gamma, which activates transcriptional pathways that increase PD-L1 production during immune responses. In many cancers, PD-L1 expression becomes elevated in tumor epithelial cells and infiltrating immune cells, linking CD274 expression to regulation of immune responses within the tumor microenvironment.
Several strong literature synonyms are associated with this immune checkpoint ligand, including PD-L1, Programmed death-ligand 1, B7-H1, and PDCD1 ligand 1. These established names help ensure consistent recognition of the CD274 immune checkpoint protein across immunology, oncology, and pathology research. In tissue-based studies, PD-L1 antibody staining is typically observed as membranous signal in epithelial cells and immune cell populations where the protein functions as a cell surface ligand regulating T cell responses. This mouse monoclonal PD-L1 antibody is microarray validated and is available from NSJ Bioreagents for investigators studying immune checkpoint signaling, tumor immunology, and immune regulation.
Optimal dilution of the microarray validated PD-L1 antibody should be determined by the researcher.
A portion of amino acids 39-191 from the human protein was used as the immunogen for this PD-L1 antibody.
Store the PD-L1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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