- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PAX8 Antibody / Paired box protein Pax-8 [clone PAX8/8651R] (V4910)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4910-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4910-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V4910SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | PAX8/8651R |
| Purity | Protein A/G affinity |
| UniProt | Q06710 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This PAX8 antibody is available for research use only. |
|
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PAX8 antibody recognizes Paired box protein Pax-8, a transcription factor encoded by the human PAX8 gene and a member of the paired box family of developmental regulators. Paired box protein Pax-8 plays a critical role in organogenesis of the thyroid gland, kidney, and Mullerian system. Because of its lineage-restricted expression, PAX8 antibody is widely used in research involving thyroid, renal, and gynecologic tissues and associated carcinomas.
Paired box protein Pax-8 contains a conserved paired DNA-binding domain that enables sequence-specific transcriptional regulation of target genes. It is essential for thyroid follicular cell differentiation and regulates genes involved in thyroid hormone synthesis, including thyroglobulin and thyroid peroxidase. In the kidney, Pax-8 contributes to renal epithelial development, while in the female reproductive tract it is involved in Mullerian duct formation. Detection of Paired box protein Pax-8 therefore reflects epithelial lineage commitment in these tissues.
PAX8 is localized to the nucleus, consistent with its role as a transcription factor. Expression is maintained in differentiated thyroid follicular cells, renal tubular epithelial cells, and epithelial cells of the fallopian tube and endometrium. In pathologic settings, PAX8 expression is retained in many thyroid carcinomas, renal cell carcinomas, and Mullerian-derived tumors, including ovarian and endometrial carcinomas. Because of this restricted expression pattern, PAX8 antibody is frequently used in studies aimed at determining tumor origin and lineage differentiation.
The PAX8 gene is located on chromosome 2q14 and encodes multiple isoforms generated through alternative splicing. Altered PAX8 expression or gene rearrangements have been associated with thyroid neoplasia and other malignancies. PAX8 antibody clone PAX8/8973R is a recombinant rabbit monoclonal antibody developed to detect Paired box protein Pax-8 in research applications. As a recombinant monoclonal antibody, clone PAX8/8973R supports consistent nuclear detection of Pax-8 in tissues relevant to developmental biology and tumor classification.
Optimal dilution of the PAX8 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 150-300) from the human protein was used as the immunogen for the PAX8 antibody.
Aliquot the PAX8 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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