- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PAX6 Antibody Recombinant Rabbit MAb PAX6/8578R [clone PAX6/8578R] (V4145)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4145-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V4145-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V4145SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | PAX6/8578R |
| Purity | Protein A/G affinity |
| UniProt | P26367 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This PAX6 antibody is available for research use only. |
|
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Paired box protein Pax-6 (PAX6) is a nuclear transcription factor encoded by the PAX6 gene and is widely recognized as a master regulator of eye formation and neural development. The protein belongs to the paired box family of transcription factors and controls transcriptional programs involved in tissue patterning and cellular differentiation. PAX6 Antibody Recombinant Rabbit MAb PAX6/8578R recognizes Pax-6 protein and supports research focused on transcriptional regulation during embryonic development and neural lineage specification.
PAX6 plays an essential role in development of the eye, central nervous system, and olfactory structures. During embryogenesis, Pax-6 regulates gene expression programs that guide morphogenesis of ocular tissues including the retina, lens, and cornea. In the developing brain, PAX6 is expressed in neural progenitor cells and contributes to regional patterning of the cerebral cortex and formation of neuronal subtypes. Because of its fundamental role in organogenesis, Pax-6 is one of the most extensively studied transcription factors in developmental biology.
The PAX6 protein contains multiple functional domains that mediate DNA binding and transcriptional regulation. An N-terminal paired domain recognizes specific DNA motifs within target gene promoters and enhancers. A homeodomain provides additional DNA-binding capability, while a C-terminal proline-serine-threonine rich transactivation domain interacts with transcriptional regulatory complexes. Through these structural domains Pax-6 coordinates expression of genes required for tissue specification and cellular differentiation.
Alterations in PAX6 expression or genetic mutations can lead to developmental abnormalities affecting ocular and neural tissues. Mutations in the PAX6 gene are associated with congenital eye disorders such as aniridia and related developmental defects. Because Pax-6 regulates numerous developmental pathways, its expression is frequently studied in models of embryogenesis, neurogenesis, and stem cell differentiation.
PAX6 antibody reagents are commonly referenced in the literature using several related names including PAX6 antibody, Pax-6 antibody, paired box protein Pax-6 antibody, and aniridia type II protein antibody. These terms all refer to the transcription factor encoded by the PAX6 gene. The recombinant rabbit monoclonal antibody PAX6/8578R recognizes Pax-6 protein and supports research examining transcriptional control mechanisms, developmental signaling pathways, and neural differentiation processes.
Optimal dilution of the PAX6 Antibody Recombinant Rabbit MAb PAX6/8578R should be determined by the researcher.
A recombinant partial protein (within amino acids 1-300) from the human protein was used as the immunogen for the PAX6 antibody.
Aliquot the PAX6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
PAX6 antibody, Pax-6 antibody, paired box protein Pax-6 antibody, aniridia type II protein antibody
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