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- Email: info@nsjbio.com
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Pax genes contain paired domains that share strong homology to genes in Drosophila which are involved in programming early development. The product of the PAX3 gene is a DNA-binding protein expressed during early neurogenesis. Pax-3 is a protein containing both a paired domain and a paired-type homeodomain. During early neurogenesis, Pax-3 expression is limited to mitotic cells in the ventricular zone of the developing spinal cord and to distinct regions in the hindbrain, midbrain and diencephalon. In 10-12 day embryos, expression of Pax-3 is also seen in neural crest cells of the developing spinal ganglia, the craniofacial mesectoderm and in limb mesenchyme. Mutations in the MITF and Pax-3 genes, encoding transcription factors, are responsible for Waardenburg syndrome II (WSII) and WSI/WSIII, respectively.
Optimal dilution of the PAX3 antibody should be determined by the researcher.
A synthetic peptide from the C-terminus region of the quail protein was used as the immunogen for the PAX3 antibody.
Aliquot the PAX3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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