- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PAX2 Antibody [clone PAX2/8671R] (V4114)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4114-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4114-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
|
V4114SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | PAX2/8671R |
| Purity | Protein A/G affinity |
| UniProt | Q02962 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This PAX2 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
PAX2 antibody, also known as Paired box protein 2 antibody, recognizes a nuclear transcription factor commonly referred to as Paired box gene 2 and PAX-2. Paired box protein 2 is encoded by the PAX2 gene located on chromosome 10q24 and belongs to the paired box family of developmental transcription factors. The protein localizes predominantly to the nucleus, where it functions as a DNA-binding regulator of gene expression during embryogenesis and tissue differentiation. PAX2 is highly expressed during kidney, urogenital tract, eye, ear, and central nervous system development, with more restricted expression in select adult tissues.
Paired box protein 2 plays a critical role in organogenesis by regulating genes involved in cell proliferation, survival, and lineage specification. It is essential for nephric duct formation, kidney morphogenesis, and optic nerve development. PAX2 antibody is widely used in research and diagnostic pathology to study renal development and to identify tumors of renal and Mullerian origin. In adult tissues, PAX2 expression is typically low or absent, but it can be reactivated in regenerative settings and in certain cancers.
Structurally, Paired box protein 2 contains a conserved paired DNA-binding domain and a partial homeodomain that mediate sequence-specific transcriptional regulation. It functions through interaction with co-regulators and chromatin remodeling complexes to activate or repress target genes. PAX2 participates in signaling pathways that include Wnt, Notch, and growth factor-mediated cascades, integrating developmental cues with transcriptional control. Isoform variation resulting from alternative splicing contributes to tissue-specific regulatory functions.
Aberrant PAX2 expression has been implicated in oncogenesis. Elevated PAX2 levels are frequently observed in renal cell carcinoma, Wilms tumor, ovarian carcinoma, and certain endometrial carcinomas. Its nuclear localization in tumor cells makes it a valuable biomarker for distinguishing primary renal neoplasms from other malignancies. In addition, PAX2 dysregulation has been associated with congenital anomalies of the kidney and urinary tract due to its developmental regulatory role.
PAX2 antibody supports investigation of embryonic development, renal pathology, and tumor biology. Clone PAX2/8671R recognizes Paired box protein 2 and is suitable for detecting PAX2 expression in relevant research applications.
Optimal dilution of the PAX2 antibody should be determined by the researcher.
A recombinant partial protein (within amino acids 223-354) from the human protein was used as the immunogen for the PAX2 antibody.
Aliquot the PAX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
