- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PAX8 Antibody / Transcriptional Network Regulator Antibody [clone PAX8/1491] (V3412)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3412-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V3412-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
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V3412SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | PAX8/1491 |
| Purity | Protein G affinity chromatography |
| UniProt | Q06710 |
| Localization | Nuclear, cytoplasmic |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This PAX-8 antibody is available for research use only. |
|
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Paired box protein Pax-8 (PAX8) is a nuclear transcription factor encoded by the PAX8 gene that functions as a central regulator of gene expression networks controlling epithelial lineage identity. As a member of the paired box (PAX) family, it binds DNA through a conserved paired domain and coordinates transcriptional programs across multiple epithelial tissues. PAX8 Antibody is uniquely positioned for mechanistic studies focused on transcriptional regulation rather than lineage identification alone.
PAX8 antibody, also referred to as Paired box protein Pax-8 antibody or Pax-8 transcription factor antibody, is particularly suited for investigating transcription factor-driven gene regulation. This PAX8 Antibody is uniquely positioned for studying transcriptional networks, cofactor interactions, and regulatory complexes, distinguishing this page from lineage-focused or diagnostic applications. Nuclear detection reflects direct engagement of PAX8 with chromatin and transcriptional machinery.
Functionally, PAX8 interacts with co-regulators and other transcription factors to form multi-protein complexes that control gene activation and repression. It regulates genes involved in differentiation, proliferation, and epithelial organization, acting as a node within larger transcriptional networks. These interactions allow coordinated control of gene expression rather than isolated transcriptional events.
PAX8 activity is integrated with signaling pathways and epigenetic regulation, enabling dynamic modulation of gene expression in response to cellular context. This makes it particularly relevant for studies examining transcription factor networks, chromatin dynamics, and regulatory feedback systems.
At the cellular level, nuclear PAX8 staining identifies cells actively engaged in transcriptional regulation, allowing correlation of protein localization with gene expression activity. Differences in staining intensity can reflect variation in transcriptional engagement across cell populations.
PAX8 Antibody therefore provides a targeted tool for studying transcriptional network regulation, with emphasis on protein-DNA interactions, cofactor recruitment, and coordinated gene expression control. This differentiates it from lineage marker pages by focusing on mechanism over identity, making it highly relevant for molecular biology and gene regulation research.
Optimal dilution of the PAX8 Antibody / Transcriptional Network Regulator Antibody should be determined by the researcher.
A human recombinant fragment (aa 60-261) was used as the immunogen for the PAX8 Antibody / Transcriptional Network Regulator Antibody.
Store the PAX-8 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
PAX8 transcriptional network antibody, Paired box protein Pax-8 gene regulation antibody, PAX8 transcription complex antibody, Pax-8 regulatory network antibody, PAX8 cofactor interaction antibody
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