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Home >> Antibodies >> Parvalbumin Antibody / PVALB

Parvalbumin Antibody / PVALB [clone PVALB/7601] (V4864)

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  Catalog No Formulation Size Price (USD)  
Image V4864-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 559
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V4864-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 259
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V4864SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 559
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Immunohistochemistry analysis of Parvalbumin / PVALB antibody (clone PVALB/7601) in human kidney tissue. FFPE human kidney tissue shows cytoplasmic HRP-DAB brown staining within tubular epithelial cells, consistent with Parvalbumin expression. Staining is predominantly localized to the cytoplasm of renal tubular structures, while surrounding glomerular and interstitial cells show minimal signal. The inset image represents a secondary antibody negative control in which PBS was used in place of the primary antibody and shows absence of specific staining. Heat induced epitope retrieval was performed by boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9, for 20 minutes followed by cooling prior to immunostaining.
SDS-PAGE analysis of purified, BSA-free PVALB antibody (clone PVALB/7601) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Host Mouse
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name PVALB/7601
Purity Protein A/G affinity
UniProt P20472
Localization Nucleus, Cytoplasm, Cell junctions
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This Parvalbumin antibody is available for research use only.
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Description

Parvalbumin antibody, also known as PVALB antibody, recognizes a small cytosolic calcium-binding protein commonly referred to as Parvalbumin. Encoded by the human PVALB gene, Parvalbumin is a member of the EF-hand calcium-binding protein family and is predominantly localized to the cytoplasm. It is highly expressed in fast-twitch skeletal muscle fibers and in specific subsets of inhibitory GABAergic interneurons within the cerebral cortex, hippocampus, and cerebellum. In the nervous system, Parvalbumin serves as a well-established marker of fast-spiking interneurons that regulate network synchronization and inhibitory tone.

Parvalbumin functions primarily as an intracellular calcium buffer. Through its two functional EF-hand domains, it binds calcium ions with high affinity, facilitating rapid calcium sequestration following action potentials. In skeletal muscle, this buffering capacity accelerates relaxation after contraction, supporting the rapid contraction-relaxation cycles characteristic of fast-twitch fibers. In neurons, Parvalbumin shapes synaptic timing and contributes to gamma oscillations and precise inhibitory control of excitatory circuits. Expression of Parvalbumin increases during postnatal development as inhibitory interneurons mature and integrate into functional neural networks.

The PVALB gene is located on chromosome 22q12.3 in humans. Structurally, Parvalbumin contains three EF-hand motifs, of which two are functional calcium-binding sites, while the third is structurally conserved but non-functional. As a member of the parvalbumin subfamily within the broader EF-hand superfamily, it shares structural homology with other calcium-binding proteins yet demonstrates highly tissue-specific expression. Parvalbumin-positive interneurons often co-localize with proteins involved in synaptic vesicle release and cytoskeletal organization, reflecting their specialized role in fast synaptic transmission.

Altered Parvalbumin expression or interneuron density has been associated with neurological and psychiatric conditions including epilepsy, schizophrenia, and autism spectrum disorders, where impaired inhibitory signaling contributes to cortical circuit dysfunction. In muscle biology, Parvalbumin levels correlate with fiber type specification and metabolic specialization, making it useful in studies of muscle adaptation and regeneration. Clone PVALB/7601 is designed to target Parvalbumin in research applications. A Parvalbumin antibody such as clone PVALB/7601 can be used to evaluate Parvalbumin expression in neurodevelopmental, neurophysiological, and skeletal muscle studies.

Application Notes

Optimal dilution of the Parvalbumin antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 1-110) from the human protein was used as the immunogen for the Parvalbumin antibody.

Storage

Aliquot the Parvalbumin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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