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Home >> Antibodies >> PARP Antibody

PARP Antibody [clone CFD-16] (RQ5290)

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Image RQ5290 Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA 100 ul 429
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Western blot testing of human Jurkat cell lysate with PARP antibody. Predicted molecular weight ~116 kDa (full length), ~24 kDa (DNA-binding domain).
Western blot testing of human Jurkat cell lysate with PARP antibody. Predicted molecular weight ~116 kDa (full length), ~24 kDa (DNA-binding domain).
Availability 1-2 weeks
Species Reactivity Human
Format Purified
Clonality Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name CFD-16
Purity Affinity purified
UniProt P09874
Applications Western blot : 1:500-1:2000
Limitations This PARP antibody is available for research use only.
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Description

The PARP1 gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [RefSeq]

Application Notes

Optimal dilution of the PARP antibody should be determined by the researcher.

Immunogen

A synthetic peptide specific to human PARP (auto-modification/catalytic segment) was used as the immunogen for the PARP antibody.

Storage

Store the PARP antibody at -20oC.

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