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Home >> Antibodies >> PARP 1 Antibody

PARP 1 Antibody (F47598)

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  Catalog No Formulation Size Price (USD)  
Image F47598-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F47598-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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PARP 1 antibody western blot analysis in NCI-H460 lysate.
PARP 1 antibody western blot analysis in NCI-H460 lysate.
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Bovine
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P09874
Applications Western blot : 1:1000
Limitations This PARP 1 antibody is available for research use only.
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Description

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. [UniProt]

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the PARP 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 590-618 from the human protein was used as the immunogen for this PARP 1 antibody.

Storage

Aliquot the PARP 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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