- Tel: 858.663.9055
- Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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PON2 is a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes.
The stated application concentrations are suggested starting points. Titration of the Paraoxonase 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 74-101 from the human protein was used as the immunogen for the Paraoxonase 2 antibody.
Aliquot the Paraoxonase 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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