- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Paired box protein Pax-8 Antibody / PAX8 [clone PAX8/6848R] (V4909)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4909-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4909-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V4909SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | PAX8/6848R |
| Purity | Protein A/G affinity |
| UniProt | Q06710 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Paired box protein Pax-8 antibody is available for research use only. |
|
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Paired box protein Pax-8 antibody recognizes PAX8, a nuclear transcription factor encoded by the PAX8 gene and a member of the paired box family of developmental regulators. Paired box protein Pax-8 plays an essential role in organogenesis of the thyroid gland, kidney, and Mullerian system. Because of its lineage-restricted expression pattern, PAX8 antibody is widely used in research involving thyroid, renal, and gynecologic tissues as well as associated carcinomas.
PAX8 contains a conserved paired DNA-binding domain that enables sequence-specific transcriptional regulation of genes critical for cellular differentiation. In the thyroid gland, Pax-8 regulates genes involved in thyroid hormone biosynthesis, including thyroglobulin and thyroid peroxidase, supporting follicular cell development and function. In the kidney, it contributes to renal epithelial differentiation, while in the female reproductive tract it participates in Mullerian duct development. Detection of Paired box protein Pax-8 therefore reflects epithelial lineage identity in these tissues.
PAX8 is localized to the nucleus, consistent with its role as a transcription factor. Expression is maintained in differentiated thyroid follicular cells, renal tubular epithelial cells, and epithelial cells of the fallopian tube and endometrium. In pathologic contexts, PAX8 expression is frequently retained in thyroid carcinomas, renal cell carcinomas, and Mullerian-derived tumors, including ovarian and endometrial carcinomas. This restricted expression profile makes PAX8 antibody valuable in studies of tumor origin and epithelial differentiation.
The PAX8 gene is located on chromosome 2q14 and encodes multiple isoforms through alternative splicing. Gene rearrangements and altered expression of PAX8 have been implicated in thyroid neoplasia and other malignancies. Paired box protein Pax-8 antibody clone PAX8/6848R is a recombinant rabbit monoclonal antibody developed to detect PAX8 in research applications, supporting consistent nuclear recognition of Pax-8 in tissues relevant to developmental biology and tumor classification.
Optimal dilution of the Paired box protein Pax-8 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 150-300) from the human protein was used as the immunogen for the Paired box protein Pax-8 antibody.
Aliquot the Paired box protein Pax-8 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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