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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Platelet-activating factor acetylhydrolase IB subunit alpha, also called Lissencephaly 1 and LIS1, is an enzyme that in humans is encoded by the PAFAH1B1 gene. This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.
Optimal dilution of the PAFAH1B1 antibody should be determined by the researcher.
An E.coli-derived human recombinant protein (amino acids I95-R410) was used as the immunogen for the PAFAH1B1 antibody.
After reconstitution, the PAFAH1B1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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