- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
p63 Antibody / Prostate Basal Cell Marker Antibody [clone rP40/8765] (V5026)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5026-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V5026-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5026SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | rP40/8765 |
| Purity | Protein A affinity |
| UniProt | Q9H3D4 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This p63 antibody is available for research use only. |
|
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Tumor protein 63 (TP63) is a nuclear transcription factor of the p53 family that is essential for maintenance of basal epithelial cells in glandular tissues, including the prostate. p63 Antibody is widely used as a prostate basal cell marker antibody for identifying basal cell layers in prostate glands, where nuclear TP63 expression provides a critical indicator of glandular integrity and epithelial organization.
p63 antibody, also known as TP63 antibody or Tumor protein 63 antibody in the literature, is strongly expressed in basal cells of benign prostate glands. As a prostate basal cell marker antibody, p63 produces distinct nuclear staining confined to the basal cell layer, while luminal secretory cells remain negative. This creates a well-defined staining pattern that outlines glandular structures and supports clear interpretation of tissue architecture.
The prostate-specific differentiator is particularly powerful in IHC-based studies, where the presence or absence of basal cells is a defining feature of glandular pathology. p63 Antibody highlights intact basal cell layers in benign glands, while prostate adenocarcinoma typically lacks this basal layer and shows little to no TP63 staining. This contrast provides a direct visual indicator of malignant transformation and is highly informative for tissue-based analysis.
TP63 isoforms, particularly deltaNp63, are associated with basal epithelial cell maintenance and contribute to the regulation of proliferation and differentiation in prostate tissue. Nuclear localization of p63 reflects its role in preserving basal cell identity and epithelial structure.
In research applications, p63 Antibody (clone rP40/8765) enables detailed evaluation of prostate gland organization, identification of basal versus luminal compartments, and assessment of epithelial integrity in both normal and disease states. The clear nuclear staining pattern allows confident interpretation even in heterogeneous tissue samples.
Tumor protein 63 antibody serves as a key marker for prostate basal cells, supporting studies of glandular biology, epithelial differentiation, and prostate cancer progression through precise and interpretable nuclear staining.
Optimal dilution of the p63 Antibody / Prostate Basal Cell Marker Antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the p63 Antibody / Prostate Basal Cell Marker Antibody.
Aliquot the p63 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
p63 prostate basal cell antibody, TP63 prostate marker antibody, Tumor protein 63 prostate gland antibody, p63 prostate epithelial marker antibody
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