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Home >> Antibodies >> p27Kip1 Antibody

p27Kip1 Antibody (F52107)

  Catalog No Formulation Size Price (USD)  
Image F52107-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F52107-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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p27Kip1 antibody western blot analysis in mouse heart tissue lysate. Predicted molecular weight ~27kDa.
Availability 1-3 business days
Species Reactivity Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P46414
Applications Western blot : 1:1000
Limitations This p27Kip1 antibody is available for research use only.
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Description

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E-and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of cyclin D-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Application Notes

Titration of the p27Kip1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 175-197 from the mouse protein was used as the immunogen for this p27Kip1 antibody.

Storage

Aliquot the p27Kip1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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